Among people aged 65 years or older, 54.9% have multiple chronic conditions. Multimorbidity includes chronic conditions affecting cardiovascular, endocrine, musculoskeletal, and gastrointestinal systems, such as hypertension, type 2 diabetes, hyperlipidemia, arthritis, back pain/sciatica, osteoporosis, cataracts, gastro-duodenal ulcers, angina/myocardial infarction, and stroke. Multimorbidity increases the risk of frailty, contributing to disability onset. Although multimorbidity directly influences disability, it also indirectly increases the risk of disability through the pathway of frailty. Because multimorbidity and frailty are closely related, managing both conditions is critical in preventing disability. With the rapid increase in the aging of the population, there has been an increasing need for developing policies for the management of multimorbid conditions and frailty in older people. The study’s aim is to propose research and policy directions for establishing an integrated healthcare system for managing older people with multimorbidity. Specific aims include (1) identifying risk factors of and effective interventions for multimorbid chronic conditions, (2) examining current multimorbidity profiles of older people, (3) reviewing national policies and management strategies for multimorbidity, (4) prioritizing action plans for developing model policies and programs for the management of frailty, and (5) generating a research and policy roadmap for developing an integrated care model for people with multimorbid conditions.